@article {wang_cortical_2020, title = {Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis}, journal = {Molecular Psychiatry}, volume = {26}, year = {2020}, note = {Publisher: Nature Publishing Group}, pages = {4331-4343}, abstract = {Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple regions of the cerebral cortex. However, findings for many regions, particularly regions outside commonly studied emotion-related prefrontal, insular, and limbic regions, are inconsistent and tentative. Also, few studies address the possibility that PTSD abnormalities may be confounded by comorbid depression. A mega-analysis investigating all cortical regions in a large sample of PTSD and control subjects can potentially provide new insight into these issues. Given this perspective, our group aggregated regional volumes data of 68 cortical regions across both hemispheres from 1379 PTSD patients to 2192 controls without PTSD after data were processed by 32 international laboratories using ENIGMA standardized procedures. We examined whether regional cortical volumes were different in PTSD vs. controls, were associated with posttraumatic stress symptom (PTSS) severity, or were affected by comorbid depression. Volumes of left and right lateral orbitofrontal gyri (LOFG), left superior temporal gyrus, and right insular, lingual and superior parietal gyri were significantly smaller, on average, in PTSD patients than controls (standardized coefficients = -0.111 to -0.068, FDR corrected P values \textless 0.039) and were significantly negatively correlated with PTSS severity. After adjusting for depression symptoms, the PTSD findings in left and right LOFG remained significant. These findings indicate that cortical volumes in PTSD patients are smaller in prefrontal regulatory regions, as well as in broader emotion and sensory processing cortical regions.}, issn = {1476-5578}, doi = {10.1038/s41380-020-00967-1}, url = {https://www.nature.com/articles/s41380-020-00967-1}, author = {Wang, Xin and Xie, Hong and Chen, Tian and Cotton, Andrew S. and Salminen, Lauren E. and Logue, Mark W. and Clarke-Rubright, Emily K. and Wall, John and Dennis, Emily L. and O{\textquoteright}Leary, Brian M. and Abdallah, Chadi G. and Andrew, Elpiniki and Baugh, Lee A. and Bomyea, Jessica and Bruce, Steven E. and Bryant, Richard and Choi, Kyle and Daniels, Judith K. and Davenport, Nicholas D. and Richard J. Davidson and DeBellis, Michael and deRoon-Cassini, Terri and Disner, Seth G. and Fani, Negar and Fercho, Kelene A. and Fitzgerald, Jacklynn and Forster, Gina L. and Frijling, Jessie L. and Geuze, Elbert and Gomaa, Hassaan and Gordon, Evan M. and Grupe, Dan and Harpaz-Rotem, Ilan and Haswell, Courtney C. and Herzog, Julia I. and Hofmann, David and Hollifield, Michael and Hosseini, Bobak and Hudson, Anna R. and Ipser, Jonathan and Jahanshad, Neda and Jovanovic, Tanja and Kaufman, Milissa L. and King, Anthony P. and Koch, Saskia B. J. and Koerte, Inga K. and Korgaonkar, Mayuresh S. and Krystal, John H. and Larson, Christine and Lebois, Lauren A. M. and Levy, Ifat and Li, Gen and Magnotta, Vincent A. and Manthey, Antje and May, Geoffrey and McLaughlin, Katie A. and Mueller, Sven C. and Nawijn, Laura and Nelson, Steven M. and Neria, Yuval and Nitschke, Jack B. and Olff, Miranda and Olson, Elizabeth A. and Peverill, Matthew and Luan Phan, K. and Rashid, Faisal M. and Ressler, Kerry and Rosso, Isabelle M. and Sambrook, Kelly and Schmahl, Christian and Shenton, Martha E. and Sierk, Anika and Simons, Jeffrey S. and Simons, Raluca M. and Sponheim, Scott R. and Murray B. Stein and Stein, Dan J. and Stevens, Jennifer S. and Straube, Thomas and Suarez-Jimenez, Benjamin and Tamburrino, Marijo and Thomopoulos, Sophia I. and van der Wee, Nic J. A. and van der Werff, Steven J. A. and van Erp, Theo G. M. and van Rooij, Sanne J. H. and van Zuiden, Mirjam and Varkevisser, Tim and Veltman, Dick J. and Vermeiren, Robert R. J. M. and Walter, Henrik and Wang, Li and Zhu, Y. E. and Zhu, Xi and Paul M. Thompson and Morey, Rajendra A. and Liberzon, Israel} }