%0 Journal Article %J Psychosomatic Medicine %D 2017 %T Dimensions of Adversity, Physiological Reactivity, and Externalizing Psychopathology in Adolescence: Deprivation and Threat %A Busso, Daniel S. %A McLaughlin, Katie A. %A Sheridan, Margaret A. %K Adolescent %K Child abuse %K exposure to violence %K Female %K Humans %K Hypothalamo-Hypophyseal System %K Male %K Mental Disorders %K Parasympathetic Nervous System %K Pituitary-Adrenal System %K Poverty %K Sympathetic Nervous System %X {OBJECTIVE: Dysregulation of autonomic nervous system and hypothalamic-pituitary-adrenal (HPA) axis function is a putative intermediate phenotype linking childhood adversity (CA) with later psychopathology. However, associations of CAs with autonomic nervous system and HPA-axis function vary widely across studies. Here, we test a novel conceptual model discriminating between distinct forms of CA (deprivation and threat) and examine their independent associations with physiological reactivity and psychopathology. METHODS: Adolescents (N = 169; mean [SD] age, 14.9 [1.4] years) with a range of interpersonal violence (e.g., maltreatment, community violence) and poverty exposure participated in the Trier Social Stress test (TSST). During the TSST, electrocardiogram, impedance cardiograph, salivary cortisol, and dehydroepiandrosterone-sulfate data were collected. We compared the associations of poverty (an indicator of deprivation) and interpersonal violence (an indicator of threat) on sympathetic, parasympathetic, and HPA-axis reactivity to the TSST, and assessed whether these differences mediated the association of adversity with internalizing and externalizing symptoms. RESULTS: Exposure to poverty and interpersonal violence was associated with psychopathology. Interpersonal violence, adjusting for poverty, was associated with blunted sympathetic (b = 1.44 %B Psychosomatic Medicine %V 79 %P 162–171 %8 mar %G eng %N 2 %R 10.1097/PSY.0000000000000369