Altered Neural Processing of Threat-Related Information in Children and Adolescents Exposed to Violence: A Transdiagnostic Mechanism Contributing to the Emergence of Psychopathology
Publication information:
Weissman, D. G., Jenness, J. L., Colich, N. L., Miller, A. B., Sambrook, K. A., Sheridan, M. A., & McLaughlin, K. A. (2020). Altered Neural Processing of Threat-Related Information in Children and Adolescents Exposed to Violence: A Transdiagnostic Mechanism Contributing to the Emergence of Psychopathology. Journal of the American Academy of Child & Adolescent Psychiatry, 59(11), 1274-1284. https://doi.org/10.1016/j.jaac.2019.08.471
Abstract
{OBJECTIVE: Exposure to violence in childhood is associated with increased risk for multiple forms of internalizing and externalizing psychopathology. We evaluated how exposure to violence in early life influences neural responses to neutral and threat-related stimuli in childhood and adolescence, developmental variation in these associations, and whether these neural response patterns convey transdiagnostic risk for psychopathology over time. METHOD: Participants were 149 youth (75 female youth), ages 8 to 17 (M =12.8